Pep Guardiola side are currently sitting comfortably on top with 14 points gap between them and second placed Manchester United.
The game is expected to kick off at 5:30pm GMT.
Both managers have fielded a strong starting XI for the game as Guardiola started the game with Gabriel Jesus leading the attack.
Also, Kevin De Bruyne makes his 250th appearance for City in the Premier League, there were reports he wouldn't be available.
While Ole Gunnar Solskjaer is without Edinson Cavani due to injury. Also Paul Pogba and Juan Mata are still recovering from injuries.
The good news for Red Devils is that Anthony Martial passed a late fitness test as he will lead the attack.
Man United XI: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, James, Fernandes, Rashford, Martial.
Manchester City starting XI :Ederson, Cancelo, Dias, Stones, Zinchenko, Rodrigo, Gundogan, De Bruyne (C), Mahrez, Sterling, Jesus
Manchester City subs: Steffen, Walker, Aguero, Laporte, Bernardo, Torres, Mendy, Fernandinho, Foden.
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