The 27-year-old had been named in the world champions' squad for upcoming fixtures against Croatia and Sweden.
Speaking at his press conference after the squad announcement, Deschamps said: "I was led, at the very last minute, to make a change in the list. Paul Pobga was in this list. Unfortunately for him, he took a test yesterday, which turned out positive. So at the last moment, I had to replace him with Eduardo Camavinga".
Pogba has been replaced in Deschamps' squad by Rennes midfielder Camavinga, while international team-mate Tanguy Ndombele of Tottenham also misses out.
Pogba will have to spend 14 days in isolation. The French man will miss the start of Man Utd's pre-season preparations.
A statement from United read: "Pogba has been replaced in the squad after testing positive for COVID-19. The midfielder will be unable to add to his 69 caps and 10 goals for his country in the games next month. Everybody at United wishes Paul a speedy recovery ahead of the new season."
Manchester United's first game of the 2020-21 Premier League season, against Crystal Palace on September 19.
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