Recall that the Gunners hosted Tottenham last week which Mikel Arteta recorded a 2-1 over Jose Mourinho.
Meanwhile this game is expected to be another difficult game for Arsenal given the form of West Ham this season.
It's understood that David Moyes side are pushing a spot in Europe next season.
Ahead of the game, Mikel Arteta has made three changes as Pablo Mari comes in for Gabriel Magalhães, Callum Chambers for Hector Bellerin.
While Bukayo Saka has recovered from an injury which saw him miss the 1-0 loss against Olympiacos on Thursday. But the Gunners qualified for the quarter-final with a 3-2 aggregate score.
Also, Mikel Arteta has started Pierre-Emerick Aubameyang who missed the Tottenham game due to disciplinary issues. The captain will lead the attack along with Alexandre Lacazette.
West Ham XI: Fabianski; Coufal, Dawson, Diop, Cresswell; Soucek, Rice; Lingard, Bowen, Benrahma; Antonio.
Arsenal XI: Leno; Chambers, Luiz, Mari, Tierney; Partey, Xhaka; Saka, Ødegaard, Aubameyang, Lacazette.
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