The Gunners will be hoping to extend their lead to five points with a win after Manchester City lost 2-1 to Brentford.
Mikel Arteta has started William Saliba and Gabriel Magalhães at the back line while Granit Xhaka and Partey in the midfield.
Gabriel Jesus, Martinelli and Saka are expected to lead the attack up front.
Meanwhile, Julen Lopetegui is set to take charge of his first game as Wolverhampton manager.
Recall that the Julen takes charges of Wolves after he left Spanish side Sevilla. The former Real Madrid boss has replaced Bruno Laige who was sacked few weeks ago.
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