If they beat the Saints, the Gunners might increase their margin of victory at the top of the Premier League standings to seven points.
The team of Mikel Arteta has lost its previous two games after blowing two-goal leads against Liverpool and West Ham.
Arteta would want his team to perform at their best tonight with seven games remaining.
Oleksandr Zinchenko has rejoined the Arsenal squad in the meantime. Due to a groin injury, the 25-year-old Ukraine international missed last weekend's trip to West Ham.
Because he can play as a central midfielder more effectively than Kieran Tierney, who played in that position in the most recent game, Zinchenko has been essential to the way Mikel Arteta's team plays.
Kieran Tierney has moved back to the bench as Zinchenko has returned.
Granit Xhaka, however, is unable to play because of a sickness.
Granit Xhaka was removed from the team this morning, according to Mikel Arteta, because he felt sick.
Fabio Vieira has been named to the midfield with Thomas Partey and Martin Odegaard.
Arsenal: Ramsdale, White, Holding, Gabriel, Zinchenko, Partey, Vieira, Odegaard, Saka, Martinelli, Gabriel Jesus
Southampton: Bazunu, Walker-Peters, Bella-Kotchap, Bednarek, Perraud, Lavia, Ward-Prowse, Alcaraz, Elyounoussi, Walcott, Armstrong
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